概述

  • 产品名称
  • 描述
    兔多克隆抗体to CRMP4
  • 特异性
    No cross reactivity was detected with CRMP1, CRMP2, CRMP3 or CRMP5.
  • 经测试应用
    适用于: WB, IHC-Fr, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator (Type 4).

性能

应用

Our Abpromise guarantee covers the use of ab36204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Predicted molecular weight: 65 kDa.
IHC-Fr 1/500.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能
    Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
  • 组织特异性
    Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
  • 序列相似性
    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
  • 翻译后修饰
    Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • 细胞定位
    Cytoplasm. Cell projection > growth cone. Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Collapsin response mediator protein 4 antibody
    • Collapsin response mediator protein 4 long antibody
    • CRMP 4 antibody
    • CRMP-4 antibody
    • CRMP4 antibody
    • Dihydropyrimidinase like 3 antibody
    • Dihydropyrimidinase related protein 3 antibody
    • Dihydropyrimidinase-related protein 3 antibody
    • DPYL3_HUMAN antibody
    • DPYSL3 antibody
    • DRP 3 antibody
    • DRP-3 antibody
    • DRP3 antibody
    • LCRMP antibody
    • TUC4 antibody
    • ULIP 1 antibody
    • ULIP antibody
    • ULIP-1 antibody
    • ULIP1 antibody
    • UNc 33 like phosphoprotein 1 antibody
    • Unc 33 like phosphoprotein antibody
    • Unc-33-like phosphoprotein 1 antibody
    see all

图片

  • All lanes : Anti-CRMP4 antibody (ab36204)

    Lane 1 : E.coli lysate transformed with cDNA of human CRMP1
    Lane 2 : E.coli lysate transformed with cDNA of human CRMP2
    Lane 3 : E.coli lysate transformed with cDNA of human CRMP3
    Lane 4 : E.coli lysate transformed with cDNA of human CRMP4
    Lane 5 : E.coli lysate transformed with cDNA of human CRMP5


    Predicted band size : 65 kDa
    Observed band size : 65 kDa

文献

This product has been referenced in:
  • Yoneda A  et al. A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol 32:1788-804 (2012). Read more (PubMed: 22431514) »

See 1 Publication for this product

客户评价及客户问答

Thank you for your clarification.

I can confirm the concentration of ab66219 (Batch: GR9812) of this ab is 1 mg/ml. The other antibody ab36204 (Lot: GR42382) is not affinity purified but whole antiserum so the IgG is not quantified. However, ...

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Thank you for your enquiry and your interest in our products.

This is to confirm that we can only provide the concentration for affinity purified antibodies. For whole serum or supernatant we do not quantify the IgG concentration. I have cont...

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My colleague Teresa has forwarded your request to our team.

I have checked the datasheets for the PFA- perfusion fixed frozen section application (IHC-FoFr), andthe antibodiesare all not tested for this. This means unfortunately, that we cann...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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