概述

  • 产品名称
  • 描述
    兔多克隆抗体to CRMP4
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 422 - 567 of Human CRMP4 (NM_001387).

  • 阳性对照
    • WB: Human fetal brain lysate IHC-P: Human fetal skeletal muscle

性能

应用

Our Abpromise guarantee covers the use of ab101009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 61 kDa (predicted molecular weight: 62 kDa).
IHC-P 1/100 - 1/500.

靶标

  • 功能
    Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
  • 组织特异性
    Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
  • 序列相似性
    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
  • 翻译后修饰
    Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • 细胞定位
    Cytoplasm. Cell projection > growth cone. Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Collapsin response mediator protein 4 antibody
    • Collapsin response mediator protein 4 long antibody
    • CRMP 4 antibody
    • CRMP-4 antibody
    • CRMP4 antibody
    • Dihydropyrimidinase like 3 antibody
    • Dihydropyrimidinase related protein 3 antibody
    • Dihydropyrimidinase-related protein 3 antibody
    • DPYL3_HUMAN antibody
    • DPYSL3 antibody
    • DRP 3 antibody
    • DRP-3 antibody
    • DRP3 antibody
    • LCRMP antibody
    • TUC4 antibody
    • ULIP 1 antibody
    • ULIP antibody
    • ULIP-1 antibody
    • ULIP1 antibody
    • UNc 33 like phosphoprotein 1 antibody
    • Unc 33 like phosphoprotein antibody
    • Unc-33-like phosphoprotein 1 antibody
    see all

Anti-CRMP4 antibody 图像

  • Anti-CRMP4 antibody (ab101009) at 1/1000 dilution + Human fetal brain lysate

    Predicted band size : 62 kDa
    Observed band size : 61 kDa (why is the actual band size different from the predicted?)
  • ab101009, at a 1/100 dilution, staining CRMP4 in formalin fixed, paraffin embedded Human fetal skeletal muscle. The image shows cytoplasmic staining of the antibody.

Anti-CRMP4 antibody (ab101009)参考文献

This product has been referenced in:
  • Chen SL  et al. Targeting CRMP-4 by lentivirus-mediated RNA interference inhibits SW480 cell proliferation and colorectal cancer growth. Exp Ther Med 12:2003-2008 (2016). WB ; Human . Read more (PubMed: 27698685) »

See 1 Publication for this product

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