The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
功能Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
序列相似性Belongs to the bZIP family. CREBRF subfamily. Contains 1 bZIP (basic-leucine zipper) domain.
翻译后修饰Probably degraded by the proteasome.
细胞定位Nucleus. Colocalizes with CREB3 in nuclear foci.