概述

  • 产品名称Anti-CREB3L1抗体
    参阅全部 CREB3L1 一抗
  • 描述
    山羊多克隆抗体to CREB3L1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    C-DFSHSKEWFHDRD

    , corresponding to C-terminal amino acids 497-509 of Human CREB3L1 (NP_443086.1).

  • 阳性对照
    • A549 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab109099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 57 kDa.

靶标

  • 功能Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
  • 组织特异性Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
  • 序列相似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 翻译后修饰Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • 细胞定位Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BBF-2 homolog antibody
    • CAMP responsive element binding protein 3 like 1 antibody
    • cAMP-responsive element-binding protein 3-like protein 1 antibody
    • CR3L1_HUMAN antibody
    • Creb3l1 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 1 antibody
    • OASIS antibody
    • Old astrocyte specifically-induced substance antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
    see all

Anti-CREB3L1 antibody 图像

  • Anti-CREB3L1 antibody (ab109099) at 3 µg/ml + A549 cell lysate
    Developed using the ECL technique

    Predicted band size : 57 kDa

Anti-CREB3L1 antibody (ab109099)参考文献

ab109099 has not yet been referenced specifically in any publications.

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