概述

  • 产品名称Anti-CPT2抗体
    参阅全部 CPT2 一抗
  • 描述
    小鼠单克隆抗体to CPT2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment: WFDKSFNLII AKDGSTAIHF EHSWGDGVAV LRFFNEVFKD STQTPAVTPQ SQPATTDSTV TVQKLNFELT DALKTGITAA KEKFDATMKT LTIDCVQFQR , corresponding to amino acids 351-451 of Human CPT2

应用

Our Abpromise guarantee covers the use of ab54589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 通路Lipid metabolism; fatty acid beta-oxidation.
    • 疾病相关Defects in CPT2 are the cause of carnitine palmitoyltransferase 2 deficiency (CPT2D) [MIM:255110, 600649]; also known as CPT-II deficiency or CPT2 deficiency. CPT2D is an autosomal recessive disorder characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are triggered by prolonged exercise, fasting or viral infection and patients are usually young adults. In addition to this classical, late-onset, muscular type, a hepatic or hepatocardiomuscular form has been reported in infants. Clinical pictures in these children or neonates include hypoketotic hypoglycemia, liver dysfunction, cardiomyopathy and sudden death.
      Defects in CPT2 are the cause of carnitine palmitoyltransferase 2 deficiency, lethal neonatal (CPT2D-LN) [MIM:608836]; also known as lethal neonatal CPT-II deficiency. It is a lethal neonatal form of CPT2D. This rarely presentation is antenatal with cerebral periventricular cysts and cystic dysplastic kidneys. The clinical variability of the disease is likely attributed to the variable residual enzymatic activity.
    • 序列相似性Belongs to the carnitine/choline acetyltransferase family.
    • 细胞定位Mitochondrion inner membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Carnitine O palmitoyltransferase 2 antibody
      • Carnitine O palmitoyltransferase 2 mitochondrial antibody
      • Carnitine O-palmitoyltransferase 2 antibody
      • Carnitine palmitoyltransferase 2 antibody
      • Carnitine palmitoyltransferase II antibody
      • CPT 1 antibody
      • CPT 2 antibody
      • CPT II antibody
      • CPT1 antibody
      • CPT2 antibody
      • CPT2_HUMAN antibody
      • CPTASE antibody
      • CPTII antibody
      • IIAE4 antibody
      • mitochondrial antibody
      see all

    Anti-CPT2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54589 CPT2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-CPT2 antibody (ab54589)参考文献

    ab54589 has not yet been referenced specifically in any publications.

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