概述

  • 产品名称Anti-CPT1A抗体
    参阅全部 CPT1A 一抗
  • 描述
    山羊多克隆抗体to CPT1A
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    C-DPAQTVEQRLKLFK

    , corresponding to internal sequence amino acids 621-634 of Human CPT1A

  • 阳性对照
    • Human Liver lysate

性能

应用

Our Abpromise guarantee covers the use of ab53532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 86 kDa).
IHC-P Use a concentration of 4 - 6 µg/ml.

靶标

  • 组织特异性Strong expression in kidney and heart, and lower in liver and skeletal muscle.
  • 通路Lipid metabolism; fatty acid beta-oxidation.
  • 疾病相关Defects in CPT1A are the cause of carnitine palmitoyltransferase 1A deficiency (CPT1AD) [MIM:255120]; also known as CPT-I deficiency or CPT1A deficiency. CPT1AD is a rare autosomal recessive metabolic disorder of long-chain fatty acid oxidation characterized by severe episodes of hypoketotic hypoglycemia usually occurring after fasting or illness. Onset is in infancy or early childhood.
  • 序列相似性Belongs to the carnitine/choline acetyltransferase family.
  • 细胞定位Mitochondrion outer membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Carnitine O palmitoyltransferase 1 liver isoform antibody
    • Carnitine O palmitoyltransferase I antibody
    • Carnitine O palmitoyltransferase I liver isoform antibody
    • Carnitine O-palmitoyltransferase 1 antibody
    • Carnitine O-palmitoyltransferase I antibody
    • Carnitine palmitoyltransferase 1A (liver) antibody
    • Carnitine palmitoyltransferase 1A antibody
    • Carnitine palmitoyltransferase I antibody
    • Carnitine palmitoyltransferase I liver antibody
    • CPT 1 antibody
    • CPT I antibody
    • CPT1 antibody
    • CPT1 L antibody
    • CPT1-L antibody
    • Cpt1a antibody
    • CPT1A_HUMAN antibody
    • CPTI antibody
    • CPTI-L antibody
    • L CPT1 antibody
    • liver isoform antibody
    see all

Anti-CPT1A antibody 图像

  • ab53532 antibody (0.1µg/ml) staining of CPT1A in Human Liver lysate (35µg protein in RIPA buffer).

    Predicted band size : 86 kDa
    Observed band size : 80 kDa (why is the actual band size different from the predicted?)
  • ab53532 at 4µg/ml staining CPT1A in human kidney tissue section by Immunohistochemistry (Formalin/ PFA-fixed paraffin-embedded tissue sections). The tissue underwent antigen retrieval by steam in citrate buffer pH 6.0. The AP staining procedure was successfully used.

Anti-CPT1A antibody (ab53532)参考文献

This product has been referenced in:
  • Samudio I  et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 120:142-56 (2010). WB ; Human . Read more (PubMed: 20038799) »

See 1 Publication for this product

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