RabMAb

Anti-CPN1抗体[EPR6229] (ab124874)

概述

  • 产品名称Anti-CPN1抗体[EPR6229]
    参阅全部 CPN1 一抗
  • 描述
    兔单克隆抗体[EPR6229] to CPN1
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human CPN1.

  • 阳性对照
    • Human plasma, HepG2 and Human fetal liver lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab124874 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 55, 48, 27 kDa (predicted molecular weight: 52 kDa). Note: The 48-kDa form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide
ICC/IF 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
    • 组织特异性Synthesized in the liver and secreted in plasma.
    • 疾病相关Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.
    • 序列相似性Belongs to the peptidase M14 family.
    • 细胞定位Secreted > extracellular space.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACBP antibody
      • Anaphylatoxin inactivator antibody
      • Arginine carboxypeptidase antibody
      • Carboxypeptidase N catalytic chain antibody
      • Carboxypeptidase N polypeptide 1 50 kD antibody
      • Carboxypeptidase N polypeptide 1 antibody
      • Carboxypeptidase N small subunit antibody
      • CBPN_HUMAN antibody
      • CPN antibody
      • CPN1 antibody
      • Kininase 1 antibody
      • Kininase-1 antibody
      • Kininase1 antibody
      • Lysine carboxypeptidase antibody
      • Plasma carboxypeptidase B antibody
      • SCPN antibody
      • Serum carboxypeptidase N antibody
      see all

    Anti-CPN1 antibody [EPR6229] 图像

    • All lanes : Anti-CPN1 antibody [EPR6229] (ab124874) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : HepG2 lysate
      Lane 3 : Human fetal liver lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 52 kDa
      Additional bands at : 27 kDa (possible cleavage fragment),48 kDa (possible cleavage fragment).

    Anti-CPN1 antibody [EPR6229] (ab124874)参考文献

    ab124874 has not yet been referenced specifically in any publications.

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