Anti-Coxsackie Adenovirus Receptor抗体(ab82726)

概述

  • 产品名称Anti-Coxsackie Adenovirus Receptor抗体
    参阅全部 Coxsackie Adenovirus Receptor 一抗
  • 描述
    兔多克隆抗体to Coxsackie Adenovirus Receptor
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide: ILYSGDKIYD DYYPDLKGRV HFTSNDLKSG DASINVTNLQ LSDIGTYQCK , corresponding to a region within N terminal amino acids 72 - 121 of Human Coxsackie Adenovirus Receptor (NP_001329)

  • 阳性对照
    • Fetal brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab82726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
  • 组织特异性Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
  • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML.
    The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
  • 翻译后修饰N-glycosylated.
    Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
  • 细胞定位Secreted and Cell membrane. Cell junction > tight junction. Cell junction > adherens junction. Basolateral cell membrane. In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 46 kD coxsackievirus and adenovirus receptor CAR protein antibody
    • 46 kD coxsackievirus and adenovirus receptor protein antibody
    • CAR antibody
    • CAR4/6 antibody
    • Coxsackie virus and adenovirus receptor antibody
    • Coxsackie virus B receptor antibody
    • Coxsackievirus and adenovirus receptor antibody
    • Coxsackievirus B adenovirus receptor antibody
    • Coxsackievirus B-adenovirus receptor antibody
    • CVB3 binding protein antibody
    • CVB3-binding protein antibody
    • Cxadr antibody
    • CXAR_HUMAN antibody
    • hCAR antibody
    • HCVADR antibody
    see all

Anti-Coxsackie Adenovirus Receptor antibody 图像

  • Anti-Coxsackie Adenovirus Receptor antibody (ab82726) at 1 µg/ml + Fetal brain lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 41 kDa
    Observed band size : 41 kDa

Anti-Coxsackie Adenovirus Receptor antibody (ab82726)参考文献

ab82726 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 30 µg
Gel Running Conditions Reduced Denaturing (4-12% gradient)
Sample Mouse Tissue lysate - whole (Testis)
Specification Testis
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
Username

Dr. David Simmons

Verified customer

提交于 Aug 18 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"