概述

  • 产品名称Anti-COX10抗体
    参阅全部 COX10 一抗
  • 描述
    小鼠多克隆抗体to COX10
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-443 of Human COX10

  • 阳性对照
    • 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Converts protoheme IX and farnesyl diphosphate to heme O.
    • 疾病相关Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
      Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
    • 序列相似性Belongs to the ubiA prenyltransferase family.
    • 细胞定位Mitochondrion membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2410004F01Rik antibody
      • AU042636 antibody
      • COX10 antibody
      • COX10_HUMAN antibody
      • Cytochrome c oxidase assembly protein antibody
      • Cytochrome c oxidase subunit X antibody
      • Heme A farnesyltransferase antibody
      • Heme O synthase antibody
      • OTTMUSP00000006085 antibody
      • Protoheme IX farnesyltransferase, mitochondrial antibody
      • Protoheme IX farnesyltransferase, mitochondrial precursor antibody
      • RP23-78H18.1 antibody
      see all

    Anti-COX10 antibody 图像

    • All lanes : Anti-COX10 antibody (ab67197) at 1/500 dilution

      Lane 1 : COX10 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg/ml per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 48 kDa
      Observed band size : 48 kDa

    Anti-COX10 antibody (ab67197)参考文献

    ab67197 has not yet been referenced specifically in any publications.

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