概述

  • 产品名称Anti-Cox 1+2抗体
  • 描述
    山羊多克隆抗体to Cox 1+2
  • 特异性ab35995 recognises COX 1 and 2 (PGHS1/2). It reacts moderately with COX2 from most mammalian species, negligible reactivity is seen with chicken COX2 at given dilution. Reacts weakly with Chicken. Antibody reactivity and working conditions may vary between species.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Sheep
    预测可用于: all Mammals
  • 免疫原

    Full length protein corresponding to Sheep Cox 1+2.
    Database link: P05979

  • 常规说明

    Storage in frost-free freezers is not recommended.
    This product should be stored undiluted.

    Should this product contain a precipitate we recommend microcentrifugation before use.

性能

应用

Our Abpromise guarantee covers the use of ab35995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 69 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2. COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
  • 细胞定位Microsomal membrane
  • 数据库链接
  • 别名
    • COX 2 antibody
    • COX3 antibody
    • Cyclooxygenase 1 antibody
    • PCOX 1 antibody
    • PGG/HS antibody
    • PGH synthase 2 antibody
    • PGHS 1 antibody
    • PHS II antibody
    • Prostaglandin endoperoxide synthase 1 antibody
    • Prostaglandin endoperoxide synthase 2 antibody
    • PTGS2 antibody
    • TIS10 antibody
    see all

Anti-Cox 1+2 antibody (ab35995)参考文献

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