RabMAb

Anti-Cortisol Binding Globulin抗体[EPR4615] (ab110648)

概述

  • 产品名称Anti-Cortisol Binding Globulin抗体[EPR4615]
    参阅全部 Cortisol Binding Globulin 一抗
  • 描述
    兔单克隆抗体[EPR4615] to Cortisol Binding Globulin
  • 经测试应用适用于: WBmore details
    不适用于: ICC,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human Cortisol Binding Globulin.

  • 阳性对照
    • Human fetal artery, plasma and placenta lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab110648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 60 kDa (predicted molecular weight: 45 kDa).
  • 应用说明Is unsuitable for ICC,IHC-P or IP.
  • 靶标

    • 功能Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
    • 组织特异性Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
    • 疾病相关Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
    • 序列相似性Belongs to the serpin family.
    • 翻译后修饰N-glycosylated; binds 5 oligosaccharide chains.
      Glycosylation in position Asn-260 is needed for steroid binding.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CBG antibody
      • CBG_HUMAN antibody
      • corticosteroid binding globulin antibody
      • Corticosteroid-binding globulin antibody
      • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
      • Serpin A6 antibody
      • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
      • Serpina6 antibody
      • Transcortin antibody
      see all

    Anti-Cortisol Binding Globulin antibody [EPR4615] 图像

    • All lanes : Anti-Cortisol Binding Globulin antibody [EPR4615] (ab110648) at 1/1000 dilution

      Lane 1 : Human fetal artery lysate
      Lane 2 : Human plasma lysate
      Lane 3 : Human placenta lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 45 kDa
      Observed band size : 60 kDa (why is the actual band size different from the predicted?)

    Anti-Cortisol Binding Globulin antibody [EPR4615] (ab110648)参考文献

    ab110648 has not yet been referenced specifically in any publications.

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