Anti-Cortisol Binding Globulin抗体(ab113442)

概述

  • 产品名称
    Anti-Cortisol Binding Globulin抗体
    参阅全部 Cortisol Binding Globulin 一抗
  • 描述
    山羊多克隆抗体to Cortisol Binding Globulin
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide:

    KASQQINQHVKDKT

    by a Cysteine residue linker, corresponding to internal sequence amino acids 157-170 of Rat Cortisol Binding Globulin (NP_001009663.1)

  • 阳性对照
    • Rat Liver lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab113442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 45 kDa).

靶标

  • 功能
    Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
  • 组织特异性
    Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
  • 疾病相关
    Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
  • 序列相似性
    Belongs to the serpin family.
  • 翻译后修饰
    N-glycosylated; binds 5 oligosaccharide chains.
    Glycosylation in position Asn-260 is needed for steroid binding.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CBG antibody
    • CBG_HUMAN antibody
    • corticosteroid binding globulin antibody
    • Corticosteroid-binding globulin antibody
    • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpin A6 antibody
    • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpina6 antibody
    • Transcortin antibody
    see all

Anti-Cortisol Binding Globulin antibody 图像

  • Anti-Cortisol Binding Globulin antibody (ab113442) at 0.03 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 45 kDa

实验方案

Anti-Cortisol Binding Globulin antibody (ab113442)参考文献

ab113442 has not yet been referenced specifically in any publications.

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