Anti-CRF抗体[4H9] (ab35748)
Key features and details
- Mouse monoclonal [4H9] to CRF
- Suitable for: ELISA, IHC-Fr, IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-CRF抗体[4H9]
参阅全部 CRF 一抗 -
描述
小鼠单克隆抗体[4H9] to CRF -
宿主
Mouse -
特异性
Reacts with CRF. Does not react with bovine serum albumin, insulin, ovalbumin or epidermal growth factor. -
经测试应用
适用于: ELISA, IHC-Fr, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat -
免疫原
Full length protein corresponding to Human CRF.
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表位
The unique lysine residue (Lys-36) is likely to be involved in the antigenic determinant of ab35748. Lysine modification by CA blocks binding completely. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
4H9 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab35748于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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IF |
Use at an assay dependent concentration.
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IHC-Fr | (2) |
Use at an assay dependent concentration.
|
IHC-P |
1/100 - 1/7000.
|
说明 |
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ELISA
Use at an assay dependent concentration. |
IF
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
1/100 - 1/7000. |
靶标
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相关性
CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few). -
细胞定位
Cytoplasmic and Secreted -
数据库链接
- Entrez Gene: 1392 Human
- Entrez Gene: 81648 Rat
- Omim: 122560 Human
- SwissProt: P06850 Human
- SwissProt: P01143 Rat
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别名
- Corticoliberin antibody
- Corticotropin releasing factor antibody
- Corticotropin releasing hormone antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab35748 被引用在 3 文献中.
- Maejima Y et al. The hypothalamus to brainstem circuit suppresses late-onset body weight gain. Sci Rep 9:18360 (2019). PubMed: 31798010
- Manjila S et al. Hypothalamic hamartoma simulating a suprasellar arachnoid cyst: resolution of precocious puberty following microsurgical lesion resection. J Neurosurg Pediatr 14:101-7 (2014). PubMed: 24835046
- Kravchenko IV & Furalev VA Monoclonal antibodies directed against two different corticotropin-releasing factor determinants. Hybridoma 13:59-64 (1994). PubMed: 7515375