Anti-Corneodesmosin抗体(ab118835)

概述

  • 产品名称Anti-Corneodesmosin抗体
    参阅全部 Corneodesmosin 一抗
  • 描述
    兔多克隆抗体to Corneodesmosin
  • 经测试应用适用于: WB, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from Nter domain of human CDSN

性能

应用

Our Abpromise guarantee covers the use of ab118835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 51 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Important for the epidermal barrier integrity.
  • 组织特异性Exclusively expressed in skin.
  • 疾病相关Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • 细胞定位Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI747712 antibody
    • CDSN antibody
    • CDSN_HUMAN antibody
    • Corneodesmosin antibody
    • D6S586E antibody
    • DADB-141O4.5 antibody
    • Differentiated keratinocyte S protein antibody
    • HTSS antibody
    • S antibody
    • S protein antibody
    see all

Anti-Corneodesmosin antibody (ab118835)参考文献

ab118835 has not yet been referenced specifically in any publications.

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