概述

  • 产品名称Anti-Corin抗体
    参阅全部 Corin 一抗
  • 描述
    兔多克隆抗体to Corin
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 60-150 of Mouse Corin.

  • 阳性对照
    • Whole cell lysates derived from Mouse heart and Rat heart

性能

应用

Our Abpromise guarantee covers the use of ab125254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 120, 250 kDa (predicted molecular weight: 116 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.
IHC-P Use a concentration of 2 - 10 µg/ml.

靶标

  • 功能Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
  • 组织特异性Highly expressed in heart. Expressed in heart myocytes.
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 FZ (frizzled) domains.
    Contains 7 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • 翻译后修饰N-glycosylated; required for processing and activation.
    Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment.
    A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • activated protease fragment antibody
    • ATC 2 antibody
    • ATC2 antibody
    • Atrial natriuretic peptide-converting enzyme antibody
    • Atrial natriuteric peptide converting enzyme antibody
    • Corin antibody
    • Corin serine peptidase antibody
    • CORIN_HUMAN antibody
    • CRN antibody
    • Heart specific serine proteinase antibody
    • Heart specific serine proteinase ATC2 antibody
    • Heart-specific serine proteinase ATC2 antibody
    • Lrp 4 antibody
    • Lrp4 antibody
    • MGC119742 antibody
    • Pro ANP convertase antibody
    • Pro ANP converting enzyme antibody
    • Pro-ANP-converting enzyme antibody
    • TMPRSS 10 antibody
    • TMPRSS10 antibody
    • Transmembrane protease serine 10 antibody
    see all

Anti-Corin antibody 图像

  • All lanes : Anti-Corin antibody (ab125254) at 1/500 dilution

    Lane 1 : Mouse heart whole cell lysates
    Lane 2 : Rat heart whole cell lysates


    Predicted band size : 116 kDa
    Observed band size : 120 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 205 kDa. We are unsure as to the identity of these extra bands.

Anti-Corin antibody (ab125254)参考文献

ab125254 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"