概述

  • 产品名称Anti-COPZ1抗体
    参阅全部 COPZ1 一抗
  • 描述
    兔多克隆抗体to COPZ1
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from an internal sequence of human COPZ1.

  • 阳性对照
    • Human cervix carcinoma tissue. Jurkat and COS cell extracts.

性能

应用

Our Abpromise guarantee covers the use of ab74370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
IHC-P 1/50 - 1/100.

靶标

  • 功能The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
    The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
  • 序列相似性Belongs to the adaptor complexes small subunit family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5930435A22Rik antibody
    • AA407760 antibody
    • CGI 120 antibody
    • Coatomer protein complex subunit zeta 1 antibody
    • Coatomer subunit zeta 1 antibody
    • Coatomer subunit zeta-1 antibody
    • COPZ antibody
    • COPZ 1 antibody
    • COPZ1 antibody
    • COPZ1_HUMAN antibody
    • D4Ertd360e antibody
    • HSPC181 antibody
    • MGC118060 antibody
    • Zeta 1 coat protein antibody
    • zeta 1 COP antibody
    • zeta COP antibody
    • Zeta-1 COP antibody
    • Zeta-1-coat protein antibody
    • Zeta1 COP antibody
    see all

Anti-COPZ1 antibody 图像

  • ab74370 at 1/50 dilution staining COPZ1 in human cervix carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.
  • All lanes : Anti-COPZ1 antibody (ab74370) at 1/500 dilution

    Lane 1 : Jurkat cell extracts
    Lane 2 : COS cell extracts
    Lane 3 : Jurkat cell extracts with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 20 kDa
    Observed band size : 20 kDa
    Additional bands at : 28 kDa,36 kDa,47 kDa,82 kDa. We are unsure as to the identity of these extra bands.

Anti-COPZ1 antibody (ab74370)参考文献

ab74370 has not yet been referenced specifically in any publications.

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