概述

  • 产品名称Anti-COPS7A抗体
    参阅全部 COPS7A 一抗
  • 描述
    兔多克隆抗体to COPS7A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 215-264 (NLKKTIKVTT AAAAAATSQD PEQHLTELRE PAPGTNQRQP SKKASKGKGL) of Human COPS7A (NP_057403).

  • 阳性对照
    • Human fetal heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab98898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 组织特异性Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
  • 序列相似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • 翻译后修饰Phosphorylated by CK2 and PKD kinases.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • COP9 complex subunit 7a antibody
    • COP9 constitutive photomorphogenic homolog subunit 7A antibody
    • COP9 signalosome complex subunit 7a antibody
    • COP9 signalosome subunit 7A antibody
    • COPS7A antibody
    • CSN7A antibody
    • CSN7A_HUMAN antibody
    • Dermal papilla derived protein 10 antibody
    • Dermal papilla-derived protein 10 antibody
    • DERP10 antibody
    • JAB1 containing signalosome subunit 7a antibody
    • JAB1-containing signalosome subunit 7a antibody
    • SGN7a antibody
    • Signalosome subunit 7a antibody
    see all

Anti-COPS7A antibody 图像

  • Anti-COPS7A antibody (ab98898) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 30 kDa

Anti-COPS7A antibody (ab98898)参考文献

ab98898 has not yet been referenced specifically in any publications.

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