概述

  • 产品名称Anti-COPS4抗体
    参阅全部 COPS4 一抗
  • 描述
    兔多克隆抗体to COPS4
  • 经测试应用适用于: WBmore details
  • 种属反应性

    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 53-102 (VNENVSLVIS RQLLTDFCTH LPNLPDSTAK EVYHFTLEKV QPRVISFEEQ) of Rat COPS4.

  • 阳性对照
    • Rat lung lysate.

性能

应用

Our Abpromise guarantee covers the use of ab118302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 序列相似性Belongs to the CSN4 family.
    Contains 1 PCI domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CH4 antibody
    • COP9 (constitutive photomorphogenic) homolog subunit 4 antibody
    • COP9 complex homolog subunit 4 antibody
    • COP9 complex S4 antibody
    • COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody
    • COP9 constitutive photomorphogenic homolog subunit 4 antibody
    • COP9 signalosome complex subunit 4 antibody
    • COP9 signalosome subunit 4 antibody
    • COPS4 antibody
    • CSN complex subunit 4 antibody
    • CSN4 antibody
    • CSN4 SCHPO antibody
    • CSN4_HUMAN antibody
    • DCH4 antibody
    • JAB1 containing signalosome subunit 4 antibody
    • JAB1-containing signalosome subunit 4 antibody
    • MGC94896 antibody
    • SGN4 antibody
    • Signalosome subunit 4 antibody
    see all

Anti-COPS4 antibody 图像

  • Anti-COPS4 antibody (ab118302) at 1 µg/ml + Rat lung lysate at 10 µg

    Predicted band size : 46 kDa

Anti-COPS4 antibody (ab118302)参考文献

ab118302 has not yet been referenced specifically in any publications.

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