概述

  • 产品名称Anti-COPS3抗体
    参阅全部 COPS3 一抗
  • 描述
    兔多克隆抗体to COPS3
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Orangutan, Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 325-375 of Human COPS3, NP_003644.2

  • 阳性对照
    • Human prostate adenocarcinoma. Human small cell lung cancer.

性能

应用

Our Abpromise guarantee covers the use of ab84432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • 组织特异性Widely expressed. Expressed at high level in heart and skeletal muscle.
    • 序列相似性Belongs to the CSN3 family.
      Contains 1 PCI domain.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 (constitutive photomorphogenic) subunit 3 antibody
      • COP 9 complex homolog subunit 3 antibody
      • COP 9 complex S3 antibody
      • COP 9 complex subunit 3 antibody
      • COP 9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 homolog antibody
      • COP 9 signalosome complex subunit 3 antibody
      • COP 9 signalosome subunit 3 antibody
      • COP 9 subunit 3 antibody
      • COP9 (constitutive photomorphogenic) subunit 3 antibody
      • COP9 complex homolog subunit 3 antibody
      • COP9 complex S3 antibody
      • COP9 complex subunit 3 antibody
      • COP9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP9 homolog antibody
      • COP9 signalosome complex subunit 3 antibody
      • COP9 signalosome subunit 3 antibody
      • COP9 subunit 3 antibody
      • COPS 3 antibody
      • cops3 antibody
      • CSN 3 antibody
      • CSN3 antibody
      • CSN3_HUMAN antibody
      • JAB 1 containing signalosome subunit 3 antibody
      • JAB1 containing signalosome subunit 3 antibody
      • JAB1-containing signalosome subunit 3 antibody
      • SGN 3 antibody
      • SGN3 antibody
      • Signalosome subunit 3 antibody
      see all

    Anti-COPS3 antibody 图像

    • etection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human prostate adenocarcinoma.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human small cell lung cancer.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.

    Anti-COPS3 antibody (ab84432)参考文献

    ab84432 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"