Anti-Coproporphyrinogen Oxidase (CPOX)抗体(ab96061)

概述

  • 产品名称Anti-Coproporphyrinogen Oxidase (CPOX)抗体
    参阅全部 Coproporphyrinogen Oxidase (CPOX) 一抗
  • 描述
    兔多克隆抗体to Coproporphyrinogen Oxidase (CPOX)
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 139-393 of Human Coproporphyrinogen Oxidase (CPOX) (NP_000088).

  • 阳性对照
    • HCT116 whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab96061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 50 kDa.

靶标

  • 功能Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
  • 通路Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
  • 疾病相关Defects in CPOX are the cause of hereditary coproporphyria (HCP) [MIM:121300]. HCP is an acute hepatic porphyria and an autosomal dominant disease characterized by neuropsychiatric disturbances and skin photosensitivity. Biochemically, there is an overexcretion of coproporphyrin III in the urine and in the feces. HCP is clinically characterized by attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. The symptoms are generally manifested with rapid onset, and can be precipitated by drugs, alcohol, caloric deprivation, infection, endocrine factors or stress. A severe variant form is harderoporphyria, which is characterized by earlier onset attacks, massive excretion of harderoporphyrin in the feces, and a marked decrease of coproporphyrinogen IX oxidase activity.
  • 序列相似性Belongs to the aerobic coproporphyrinogen-III oxidase family.
  • 细胞定位Mitochondrion intermembrane space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Coprogen oxidase antibody
    • COPROPORPHYRIA antibody
    • Coproporphyrinogen III oxidase antibody
    • Coproporphyrinogen-III oxidase antibody
    • Coproporphyrinogenase antibody
    • COX antibody
    • CPO antibody
    • Cpox antibody
    • CPX antibody
    • HEM 6 antibody
    • Hem-6 antibody
    • Hem6 antibody
    • HEM6_HUMAN antibody
    • mitochondrial antibody
    see all

Anti-Coproporphyrinogen Oxidase (CPOX) antibody 图像

  • Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab96061) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 50 kDa

Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab96061)参考文献

ab96061 has not yet been referenced specifically in any publications.

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