Anti-Coproporphyrinogen Oxidase (CPOX)抗体(ab102938)

概述

  • 产品名称
    Anti-Coproporphyrinogen Oxidase (CPOX)抗体
    参阅全部 Coproporphyrinogen Oxidase (CPOX) 一抗
  • 描述
    兔多克隆抗体to Coproporphyrinogen Oxidase (CPOX)
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 425-454 of Human Coproporphyrinogen Oxidase (CPOX).

  • 阳性对照
    • Mouse liver tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab102938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能
    Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
  • 通路
    Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
  • 疾病相关
    Defects in CPOX are the cause of hereditary coproporphyria (HCP) [MIM:121300]. HCP is an acute hepatic porphyria and an autosomal dominant disease characterized by neuropsychiatric disturbances and skin photosensitivity. Biochemically, there is an overexcretion of coproporphyrin III in the urine and in the feces. HCP is clinically characterized by attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. The symptoms are generally manifested with rapid onset, and can be precipitated by drugs, alcohol, caloric deprivation, infection, endocrine factors or stress. A severe variant form is harderoporphyria, which is characterized by earlier onset attacks, massive excretion of harderoporphyrin in the feces, and a marked decrease of coproporphyrinogen IX oxidase activity.
  • 序列相似性
    Belongs to the aerobic coproporphyrinogen-III oxidase family.
  • 细胞定位
    Mitochondrion intermembrane space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Coprogen oxidase antibody
    • COPROPORPHYRIA antibody
    • Coproporphyrinogen III oxidase antibody
    • Coproporphyrinogen-III oxidase antibody
    • Coproporphyrinogenase antibody
    • COX antibody
    • CPO antibody
    • Cpox antibody
    • CPX antibody
    • HEM 6 antibody
    • Hem-6 antibody
    • Hem6 antibody
    • HEM6_HUMAN antibody
    • mitochondrial antibody
    see all

图片

  • Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab102938) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 50 kDa

实验方案

文献

ab102938 has not yet been referenced specifically in any publications.

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