概述

  • 产品名称Anti-COPE抗体
    参阅全部 COPE 一抗
  • 描述
    小鼠多克隆抗体to COPE
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein corresponding to amino acids 1-308 of Human COPE (NP_009194.2).

  • 阳性对照
    • Human liver lysate, COPE transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab88824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

靶标

  • 功能The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
  • 序列相似性Belongs to the COPE family.
  • 翻译后修饰Phosphorylated by PKA.
    Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.
  • 细胞定位Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110005D17Rik antibody
    • Coatomer epsilon subunit antibody
    • Coatomer protein complex subunit epsilon antibody
    • Coatomer subunit epsilon antibody
    • COPE antibody
    • COPE_HUMAN antibody
    • Cope1 antibody
    • Epsilon coat protein antibody
    • Epsilon COP antibody
    • Epsilon COP I antibody
    • Epsilon subunit of coatomer protein complex antibody
    • Epsilon-coat protein antibody
    • Epsilon-COP antibody
    • FLJ13241 antibody
    see all

Anti-COPE antibody 图像

  • Anti-COPE antibody (ab88824) at 1/500 dilution + Human liver lysate at 25 µg

    Predicted band size : 34 kDa
    Observed band size : 34 kDa
  • All lanes : Anti-COPE antibody (ab88824) at 1/500 dilution

    Lane 1 : COPE transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 34 kDa
    Observed band size : 34 kDa

Anti-COPE antibody (ab88824)参考文献

This product has been referenced in:

See 1 Publication for this product

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