概述

  • 产品名称Anti-COP抗体
    参阅全部 COP 一抗
  • 描述
    小鼠单克隆抗体to COP
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MADKVLKEKR KLFIHSMGEG TINGLLDELL QTRVLNQEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAETLGLS AGPIPGN, corresponding to amino acids 1-98 of Human COP

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
    • 组织特异性Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
    • 序列相似性Contains 1 CARD domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAR16_HUMAN antibody
      • CARD only domain-containing protein 1 antibody
      • CARD only protein antibody
      • CARD16 antibody
      • Caspase recruitment domain family, member 16 antibody
      • Caspase recruitment domain-containing protein 16 antibody
      • Caspase-1 dominant-negative inhibitor pseudo-ICE antibody
      • Caspase-1 inhibitor COP antibody
      • COP antibody
      • COP1 antibody
      • Pseudo interleukin 1 beta converting enzyme antibody
      • Pseudo interleukin-1 beta converting enzyme antibody
      • Pseudo interleukin-1beta converting enzyme antibody
      • PSEUDO-ICE antibody
      see all

    Anti-COP antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57714 COP antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-COP antibody (ab57714)参考文献

    ab57714 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"