概述

  • 产品名称Anti-COMP抗体
    参阅全部 COMP 一抗
  • 描述
    兔多克隆抗体to COMP
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide selected from the center region of human COMP, conjugated to KLH.

  • 阳性对照
    • Jurkat cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab91354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 84 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
    • 组织特异性Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
    • 疾病相关Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1) [MIM:132400]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types.
      Defects in COMP are the cause of pseudoachondroplasia (PSACH) [MIM:177170]. PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood.
    • 序列相似性Belongs to the thrombospondin family.
      Contains 4 EGF-like domains.
      Contains 1 TSP C-terminal (TSPC) domain.
      Contains 8 TSP type-3 repeats.
    • 发展阶段Present during the earliest stages of limb maturation and is later found in regions where the joints develop.
    • 结构域The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
      The TSP C-terminal domain mediates interaction with FN1 and ACAN.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody
      • Cartilage oligomeric matrix protein antibody
      • Cartilage oligomeric matrix protein precursor antibody
      • COMP antibody
      • COMP_HUMAN antibody
      • EDM 1 antibody
      • EDM1 antibody
      • EPD 1 antibody
      • EPD1 antibody
      • Epiphyseal dysplasia 1 antibody
      • Epiphyseal dysplasia 1 multiple antibody
      • Epiphyseal dysplasia multiple 1 antibody
      • MED antibody
      • MGC13181 antibody
      • MGC149768 antibody
      • PSACH antibody
      • pseudoachondroplasia (epiphyseal dysplasia 1, multiple) antibody
      • Pseudoachondroplasia antibody
      • THBS 5 antibody
      • THBS5 antibody
      • Thrombospondin 5 antibody
      • Thrombospondin-5 antibody
      • Thrombospondin5 antibody
      • TSP5 antibody
      see all

    Anti-COMP antibody 图像

    • Anti-COMP antibody (ab91354) at 1/100 dilution (temperature) + Jurkat cell lysate at 35 µg

      Predicted band size : 84 kDa

    Anti-COMP antibody (ab91354)参考文献

    ab91354 has not yet been referenced specifically in any publications.

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