概述

  • 产品名称Anti-COLQ抗体
    参阅全部 COLQ 一抗
  • 描述
    兔多克隆抗体to COLQ
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow
  • 免疫原

    A region within synthetic peptide: MVVLNPMTLG IYLQLFFLSI VSQPTFINSV LPISAALPSL DQKKRGGHKA, corresponding to N terminal amino acids 1-50 of Human COLQ.

  • 阳性对照
    • HepG2 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab49190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay 1/312500.

靶标

  • 功能Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
  • 组织特异性Found at the end plate of skeletal muscle.
  • 疾病相关Defects in COLQ are the cause of congenital myasthenic syndrome Engel type (CMSE) [MIM:603034]; also known as end-plate acetylcholinesterase deficiency or congenital myasthenic syndrome type IC (CMS-IC). CMSE is a rare autosomal recessive congenital myasthenic syndrome characterized by onset during childhood, generalized weakness, abnormal fatigability on exertion, refrectoriness to acetylcholinesterase drugs, decremental electromyographic response and morphological abnormalities of the neuromuscular junctions.
  • 序列相似性Belongs to the COLQ family.
    Contains 2 collagen-like domains.
  • 结构域The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.
  • 翻译后修饰The triple-helical tail is stabilized by disulfide bonds at each end.
  • 细胞定位Cell junction > synapse.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholinesterase collagen-like tail subunit isoform I antibody
    • Acetylcholinesterase collagenic tail peptide antibody
    • Acetylcholinesterase collagenic tail peptide precursor antibody
    • Acetylcholinesterase-associated collagen antibody
    • AChE Q subunit antibody
    • asymmetric acetylcholinesterase antibody
    • Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase antibody
    • Colq antibody
    • COLQ_HUMAN antibody
    • EAD antibody
    • OTTHUMP00000209566 antibody
    • OTTHUMP00000209567 antibody
    • single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase antibody
    see all

Anti-COLQ antibody 图像

  • Anti-COLQ antibody (ab49190) at 1.25 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution
    Developed using the ECL technique

    Predicted band size : 48 kDa
    Observed band size : 48 kDa

Anti-COLQ antibody (ab49190)参考文献

ab49190 has not yet been referenced specifically in any publications.

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