概述
- 产品名称Anti-Collagen XVII抗体[NC16A-3]
参阅全部 Collagen XVII 一抗 - 描述小鼠单克隆抗体[NC16A-3] to Collagen XVII
- 经测试应用适用于: IHC-P, ELISAmore details
- 种属反应性与反应: Human
- 免疫原
Purified recombinant NC16a-domain of human collagen XVII
- 阳性对照
- Human normal skin tissue.
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
- 存储溶液Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, PBS -
Concentration information loading... - 纯度Protein G purified
- 克隆单克隆
- 克隆编号NC16A-3
- 同种型IgG1
- 研究领域
相关产品
- Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab79878 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | 1/40. For 60 minutes at room temperature for Biotin based detection systems. May require polymer detection. For optimal staining, the sections should be pretreated with an antigen unmasking solution. | |
| ELISA | Use at an assay dependent concentration. |
靶标
- 相关性Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.
- 细胞定位Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome. 120 kDa linear IgA disease antigen and 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane.
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数据库链接
- Entrez Gene: 1308 Human
- Omim: 113811 Human
- SwissProt: Q9UMD9 Human
- Unigene: 117938 Human
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别名
- 180 kDa bullous pemphigoid antigen 2 antibody
- Alpha 1 type XVII collagen antibody
- BA16H23.2 antibody
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Anti-Collagen XVII antibody [NC16A-3] (ab79878)参考文献
ab79878 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"