Anti-Collagen VIII alpha 1抗体(ab58776)


  • 产品名称Anti-Collagen VIII alpha 1抗体
    参阅全部 Collagen VIII alpha 1 一抗
  • 描述
    兔多克隆抗体to Collagen VIII alpha 1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rabbit, Human
  • 免疫原

    A synthetic peptide corresponding to C-terminal residues of human Collagen VIII alpha 1




Our Abpromise guarantee covers the use of ab58776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent concentration. Predicted molecular weight: 73 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in artherogenesis.
      Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
    • 组织特异性Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.
    • 序列相似性Contains 1 C1q domain.
    • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
      Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.
    • 细胞定位Secreted > extracellular space > extracellular matrix > basement membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C3orf7 antibody
      • CO8A1_HUMAN antibody
      • COL8A1 antibody
      • Collagen alpha 1(VIII) chain [Precursor] antibody
      • Endothelial collagen antibody
      • MGC9568 antibody
      • Vastatin antibody
      see all

    Anti-Collagen VIII alpha 1 antibody (ab58776)参考文献

    This product has been referenced in:
    • Loeffler I  et al. Type VIII Collagen Modulates TGF-{beta}1-induced Proliferation of Mesangial Cells. J Am Soc Nephrol 22:649-63 (2011). WB ; Mouse . Read more (PubMed: 21372207) »
    • Todorovic V  et al. Detection of differentially expressed basal cell proteins by mass spectrometry. Mol Cell Proteomics 9:351-61 (2010). WB ; Mouse . Read more (PubMed: 19955077) »

    See all 3 Publications for this product

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    I have good news: the peptide is available for sale, but is currently backordered for 3 weeks.
    Once I have more information about the catalog number and datasheet I will let you know - hopefully by the end o...

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    Thank you for your inquiry.  A cross-reaction of this antibody with the collagen alpha2 (VIII) chain was not specifically tested. But I can confirm that a cross-reaction is very unlikely because the immunogen sequence only shares 66% homology with al...

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