Anti-Collagen VII抗体[LH7.2] (ab80790)


  • 产品名称Anti-Collagen VII抗体[LH7.2]
    参阅全部 Collagen VII 一抗
  • 描述
    小鼠单克隆抗体[LH7.2] to Collagen VII
  • 特异性This antibody shows no cross-reaction with Type I, II, III, IV, and V collagens, laminin, and fibronectin. It reacts with the basement membrane zone of stratified squamous epithelia. It is useful in differentiating invasive from non-invasive melanoma through clear visualization of appearance and integrity of epidermal basement membrane. It is also helpful in the identification of recessive Dystrophic Epidermolysis Bullosa (RDEB) in which Type VII collagen is defective.
  • 经测试应用适用于: IHC-Fr, Electron Microscopy, ICC/IFmore details
  • 种属反应性
    与反应: Sheep, Goat, Guinea pig, Cow, Human, Pig, Monkey, Marmoset (common)
  • 免疫原

    Insoluble fractions of Human neonatal foreskin epidermal cells.

  • 表位On non-helical (non-collagenous) C-terminal region of collagen VII and is resistant to collagenase, trypsin, pronase, neuraminidase, chondroitinase, and hyaluronidase. However, it is lost by digestion of collagen VII with pepsin.
  • 阳性对照
    • Normal skin.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 10mM PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified from the ascites fluid by Protein G chromatography.
  • 克隆单克隆
  • 克隆编号LH7.2
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域


Our Abpromise guarantee covers the use of ab80790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration. PubMed: 21939396
Electron Microscopy Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.


  • 功能Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
  • 疾病相关Epidermolysis bullosa acquisita (EBA) is an autoimmune acquired blistering skin disease resulting from autoantibodies to type VII collagen.
    Epidermolysis bullosa dystrophica, autosomal dominant
    Epidermolysis bullosa dystrophica, autosomal recessive
    Epidermolysis bullosa dystrophica, Pasini type
    Epidermolysis bullosa dystrophica, Hallopeau-Siemens type
    Transient bullous dermolysis of the newborn
    Epidermolysis bullosa dystrophica, pretibial type
    Epidermolysis bullosa dystrophica, Bart type
    Epidermolysis bullosa pruriginosa
    Nail disorder, non-syndromic congenital, 8
    Epidermolysis bullosa dystrophica, with subcorneal cleavage
  • 序列相似性Contains 1 BPTI/Kunitz inhibitor domain.
    Contains 9 fibronectin type-III domains.
    Contains 2 VWFA domains.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix > basement membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha 1 type VII collagen antibody
    • CO7A1_HUMAN antibody
    • Col7a1 antibody
    • Collagen alpha 1(VII) chain antibody
    • Collagen alpha-1(VII) chain antibody
    • Collagen type VII alpha 1 antibody
    • Collagen VII alpha 1 polypeptide antibody
    • CollagenVII antibody
    • EBD 1 antibody
    • EBD1 antibody
    • EBDCT antibody
    • EBR 1 antibody
    • EBR1 antibody
    • LC collagen antibody
    • Long chain collagen antibody
    • Long-chain collagen antibody
    see all

Anti-Collagen VII antibody [LH7.2] (ab80790)参考文献

This product has been referenced in:
  • Eldardiri M  et al. Wound contraction is significantly reduced by the use of microcarriers to deliver keratinocytes and fibroblasts in an in vivo pig model of wound repair and regeneration. Tissue Eng Part A 18:587-97 (2012). IHC-Fr ; Pig . Read more (PubMed: 21939396) »
  • Kirkham N  et al. Type VII collagen antibody LH 7.2 identifies basement membrane characteristics of thin malignant melanomas. J Pathol 157:243-7 (1989). ICC/IF, Electron Microscopy ; Human, Cow, Goat, Guinea pig, Marmoset (common), Monkey, Pig, Sheep . Read more (PubMed: 2647941) »

See all 5 Publications for this product

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