Anti-Collagen VI抗体(Biotin) (ab119300)

概述

  • 产品名称Anti-Collagen VI抗体(Biotin)
    参阅全部 Collagen VI 一抗
  • 描述
    兔多克隆抗体to Collagen VI (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: all Mammals
  • 免疫原

    The immunogen is collagen type VI purified from human and bovine placenta

  • 阳性对照
    • Human liver or prostate tissue

性能

应用

Our Abpromise guarantee covers the use of ab119300 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000 - 1/10000. Predicted molecular weight: 109 kDa.
IP Use at an assay dependent dilution.
ELISA 1/10000 - 1/50000.
IHC-P Use a concentration of 1.25 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Collagen VI acts as a cell-binding protein.
  • 疾病相关Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • 序列相似性Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha 1 (VI) chain (61 AA) antibody
    • CO6A1_HUMAN antibody
    • COL6A1 antibody
    • COL6A2 antibody
    • COL6A3 antibody
    • Collagen alpha 2(VI) chain antibody
    • Collagen alpha 3(VI) chain antibody
    • Collagen alpha-1(VI) chain antibody
    • Collagen type VI alpha 1 antibody
    • Collagen type VI alpha 2 antibody
    • Collagen type VI alpha 3 antibody
    • Collagen VI alpha 1 polypeptide antibody
    • Collagen VI alpha 2 polypeptide antibody
    • Collagen VI alpha 3 polypeptide antibody
    • CollagenVI antibody
    • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
    • OPLL antibody
    • PP3610 antibody
    see all

Anti-Collagen VI antibody (Biotin) 图像

  • ab119300, at a 1.25µg/ml, staining Human Collagen VI in liver, using Immunohistochemistry, Formalin/PFA-fixed parraffin-embedded tissue.
  • ab119300, at a 1.25µg/ml, staining Human Collagen VI in prostate, using Immunohistochemistry, Formalin/PFA-fixed parraffin-embedded tissue.

Anti-Collagen VI antibody (Biotin) (ab119300)参考文献

ab119300 has not yet been referenced specifically in any publications.

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After review of our catalog, my first recommendation is anti-Collagen VI, ab119300. This product is guaranteed in IHC-P and the images on...

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