Anti-Collagen VI抗体(ab118955)

概述

  • 产品名称Anti-Collagen VI抗体
    参阅全部 Collagen VI 一抗
  • 描述
    兔多克隆抗体to Collagen VI
  • 特异性Percentage of reactivity with all isoforms of COL6 has not been determined.
  • 经测试应用适用于: WB, IP, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Cow, Human
    预测可用于: all Mammals
  • 免疫原

    Other Immunogen Type corresponding to Collagen VI. Collagen VI antibody was raised against Collagen Type VI from human and bovine placenta.

  • 阳性对照
    • Human breast tissue; Human lung tissue

性能

应用

Our Abpromise guarantee covers the use of ab118955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 109 kDa.
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Collagen VI acts as a cell-binding protein.
  • 疾病相关Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • 序列相似性Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha 1 (VI) chain (61 AA) antibody
    • CO6A1_HUMAN antibody
    • COL6A1 antibody
    • COL6A2 antibody
    • COL6A3 antibody
    • Collagen alpha 2(VI) chain antibody
    • Collagen alpha 3(VI) chain antibody
    • Collagen alpha-1(VI) chain antibody
    • Collagen type VI alpha 1 antibody
    • Collagen type VI alpha 2 antibody
    • Collagen type VI alpha 3 antibody
    • Collagen VI alpha 1 polypeptide antibody
    • Collagen VI alpha 2 polypeptide antibody
    • Collagen VI alpha 3 polypeptide antibody
    • CollagenVI antibody
    • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
    • OPLL antibody
    • PP3610 antibody
    see all

Anti-Collagen VI antibody 图像

  • ab118955 at 2.5 ug/ml staining COL6A1 in formalin fixed paraffin embedded Human breast tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

  • ab118955 at 2.5 ug/ml staining COL6A1 in paraffin embedded formalin fixed Human lung tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Collagen VI antibody (ab118955)参考文献

ab118955 has not yet been referenced specifically in any publications.

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