概述

  • 产品名称Anti-Collagen III抗体
    参阅全部 Collagen III 一抗
  • 描述
    兔多克隆抗体to Collagen III
  • 经测试应用适用于: IHC-P, ICC/IF, ELISA, RIAmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Full length native protein (purified from skin) (Rat).

  • 阳性对照
    • Rat skin or liver.

性能

应用

Our Abpromise guarantee covers the use of ab23746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/200 - 1/600. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
RIA Use at an assay dependent concentration.

靶标

  • 功能Collagen type III occurs in most soft connective tissues along with type I collagen.
  • 疾病相关Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.
    Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
    Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.
  • 序列相似性Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 VWFC domain.
  • 翻译后修饰Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha 1 type III collagen antibody
    • Alpha1 (III) collagen antibody
    • CO3A1_HUMAN antibody
    • COL 3A1 antibody
    • COL3A1 antibody
    • Collagen alpha 1(III) chain antibody
    • Collagen alpha-1(III) chain antibody
    • Collagen III alpha 1 chain precursor antibody
    • Collagen III alpha 1 polypeptide antibody
    • Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody
    • Collagen type III alpha 1 antibody
    • Collagen type III alpha 1 chain antibody
    • Collagen type III alpha antibody
    • Collagen, fetal antibody
    • EDS4A antibody
    • Ehlers Danlos syndrome type IV, autosomal dominant antibody
    • Fetal collagen antibody
    • Type III collagen antibody
    see all

Anti-Collagen III antibody (ab23746)参考文献

This product has been referenced in:
  • Bostick B  et al. Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity. Metabolism 63:1000-11 (2014). IHC-P ; Mouse . Read more (PubMed: 24933400) »
  • Whaley-Connell AT  et al. Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats. Metabolism 62:1761-71 (2013). Rat . Read more (PubMed: 24075738) »

See all 3 Publications for this product

Product Wall

Thank you for your enquiry. I would recommend that you aliquot your antibodies and only dilute when you are ready to use the antibody. Also, I would recommend that you dilute them into PBS, not TBS. Unfortunately, we do not have a protocol specifically...

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Thank you for your enquiry. First, let me direct you a very informative website about IHC called IHC World. The web address is www.ihcworld.com. You can search that website for streptavidin, and then click on the Immunohistochemistry Introduction link....

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I am in touch with the supplier of ab13966 and will let you know any information I receive as soon as possible. Regarding ab23746, the customer can purchase Hyaluronidase from the company Biologo (http://www.biologo.de/englisch/), reference HYA02-50.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"