Anti-Collagen I + II + III抗体[NLI/22] (ab53925)

概述

  • 产品名称Anti-Collagen I + II + III抗体[NLI/22]
  • 描述
    小鼠单克隆抗体[NLI/22] to Collagen I + II + III
  • 特异性ab53925 does not react with human collagen types IV, V or VI, human plasma proteins or albumin from various species.
  • 经测试应用适用于: ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein (purified) (Human)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 0.1% mannitol, 0.1M Sodium chloride, 0.01M Sodium phosphate, pH 7.5
  • Concentration information loading...
  • 纯化说明ab53925 was purified by Gel Filtration chromatography.
  • 克隆单克隆
  • 克隆编号NLI/22
  • 同种型IgM
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab53925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/500 - 1/2000.
ICC/IF 1/5 - 1/20.

靶标

  • 相关性Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
  • 数据库链接
  • 别名
    • AOM antibody
    • COL11A3 antibody
    • COL1A2 antibody
    • COL3A1 antibody
    • Collagen I alpha 1 polypeptide antibody
    • Collagen I alpha 2 polypeptide antibody
    • Collagen II alpha 1 polypeptide antibody
    • Collagen III alpha 1 polypeptide antibody
    • EDS4A antibody
    • OI4 antibody
    see all

Anti-Collagen I + II + III antibody [NLI/22] (ab53925)参考文献

ab53925 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application ELISA
Sample Human Purified protein (Collagen type III (also bovine type II collagen))
Specification Collagen type III (also bovine type II collagen)
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
Type Indirect
Username

Ben Maddox

Verified customer

提交于 Dec 14 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"