Anti-Collagen I + II + III + IV + V抗体(ab36064)
Key features and details
- Rabbit polyclonal to Collagen I + II + III + IV + V
- Suitable for: ELISA, IHC-Fr, ICC/IF
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Collagen I + II + III + IV + V抗体 -
描述
兔多克隆抗体to Collagen I + II + III + IV + V -
宿主
Rabbit -
经测试应用
适用于: ELISA, IHC-Fr, ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Full length native Collagen I + II + III + IV + V proteins (purified) from human placenta.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.50
Constituents: 0.1% Dextran, 0.87% Sodium chloride, 0.164% Sodium phosphate, 0.1% Mannitol -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
This antibody is affinity isolated. It was purified by affinity chromatography on immobilized Collagen types I-V. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab36064于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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说明 |
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ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
靶标
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功能
Type I collagen is a member of group I collagen (fibrillar forming collagen). -
组织特异性
Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. -
疾病相关
Caffey disease
Ehlers-Danlos syndrome, classic type
Ehlers-Danlos syndrome 7A
Osteogenesis imperfecta 1
Osteogenesis imperfecta 2
Osteogenesis imperfecta 3
Osteogenesis imperfecta 4
Osteoporosis
A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. -
序列相似性
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain. -
结构域
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. -
翻译后修饰
Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group. -
细胞定位
Secreted, extracellular space, extracellular matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 1277 Human
- Entrez Gene: 1280 Human
- Entrez Gene: 1281 Human
- Entrez Gene: 1282 Human
- Entrez Gene: 1289 Human
- Omim: 120130 Human
- Omim: 120140 Human
- Omim: 120150 Human
see all -
别名
- Alpha-1 type I collagen antibody
- CO1A1_HUMAN antibody
- COL1A1 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab36064 被引用在 5 文献中.
- Lau S et al. Venous and Arterial Endothelial Cells from Human Umbilical Cords: Potential Cell Sources for Cardiovascular Research. Int J Mol Sci 22:N/A (2021). PubMed: 33478148
- Luong B et al. The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen. PLoS One 13:e0203053 (2018). PubMed: 30204757
- Schwenk R et al. The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells. Oncotarget 8:77622-77633 (2017). PubMed: 29100413
- Sur S et al. Synergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct. Biomater Sci 2:903-914 (2014). PubMed: 25530849
- Trescher K et al. Test system for evaluating the influence of polymer properties on primary human keratinocytes and fibroblasts in mono- and coculture. J Biotechnol 166:58-64 (2013). PubMed: 23643480