概述

  • 产品名称
    Anti-Colec12抗体
    参阅全部 Colec12 一抗
  • 描述
    兔多克隆抗体to Colec12
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 109-158 (LSTFRSDILD LRQQLREITE KTSKNKDTLE KLQASGDALV DRQSQLKETL) of Human Colec12 (NP_569057).

  • 阳性对照
    • 721_B cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab81136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 82 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

靶标

  • 功能
    Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
  • 组织特异性
    Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
  • 序列相似性
    Contains 1 C-type lectin domain.
    Contains 3 collagen-like domains.
  • 细胞定位
    Membrane. Forms clusters on the cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CL P1 antibody
    • CL-P1 antibody
    • CLP1 antibody
    • COL12_HUMAN antibody
    • COLEC 12 antibody
    • colec12 antibody
    • Collectin placenta 1 antibody
    • Collectin placenta protein 1 antibody
    • Collectin sub family member 12 antibody
    • Collectin-12 antibody
    • hCL P1 antibody
    • hCL-P1 antibody
    • NSR2 antibody
    • Nurse cell scavenger receptor 2 antibody
    • SCARA4 antibody
    • Scavenger receptor class A member 4 antibody
    • Scavenger receptor with C type lectin antibody
    • Scavenger receptor with C-type lectin antibody
    • SRCL antibody
    see all

图片

  • Anti-Colec12 antibody (ab81136) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 82 kDa
    Observed band size : 82 kDa

实验方案

文献

ab81136 has not yet been referenced specifically in any publications.

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