概述

  • 产品名称Anti-Colec12抗体
    参阅全部 Colec12 一抗
  • 描述
    小鼠单克隆抗体to Colec12
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Mouse, Rat, Cow, Human
  • 免疫原

    Recombinant fragment: AISTNSELST FRSDILDLRQ QLREITEKTS KNKDTLEKLQ ASGDALVDRQ SQLKETLENN SFLITTVNKT LQAYNGYVTN LQQDTSVLQG NLQNQMYSHN, corresponding to amino acids 101-200 of Human Colec12 (AAH60789) with a proprietory tag.

  • 阳性对照
    • Recombinant tagged human Colec12 fragment.

性能

应用

Our Abpromise guarantee covers the use of ab77677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
    • 组织特异性Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
    • 序列相似性Contains 1 C-type lectin domain.
      Contains 3 collagen-like domains.
    • 细胞定位Membrane. Forms clusters on the cell surface.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CL P1 antibody
      • CL-P1 antibody
      • CLP1 antibody
      • COL12_HUMAN antibody
      • COLEC 12 antibody
      • colec12 antibody
      • Collectin placenta 1 antibody
      • Collectin placenta protein 1 antibody
      • Collectin sub family member 12 antibody
      • Collectin-12 antibody
      • hCL P1 antibody
      • hCL-P1 antibody
      • NSR2 antibody
      • Nurse cell scavenger receptor 2 antibody
      • SCARA4 antibody
      • Scavenger receptor class A member 4 antibody
      • Scavenger receptor with C type lectin antibody
      • Scavenger receptor with C-type lectin antibody
      • SRCL antibody
      see all

    Anti-Colec12 antibody 图像

    • Anti-Colec12 antibody (ab77677) at 1 µg/ml + Recombinant tagged human Colec12 fragment at 0.2 µg

      Secondary
      Goat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 82 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    Anti-Colec12 antibody (ab77677)参考文献

    ab77677 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"