概述

  • 产品名称Anti-COG7抗体
    参阅全部 COG7 一抗
  • 描述
    山羊多克隆抗体to COG7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Dog, Cynomolgus Monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-KTRPEDYRQVSK

    , corresponding to internal sequence amino acids 741-752 of Human COG7 (NP_705831.1)

  • 阳性对照
    • HeLa, Jurkat or MOLT4 golgi lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 85 kDa.
    Peptide ELISA: antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Required for normal Golgi function.
    • 疾病相关Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
    • 序列相似性Belongs to the COG7 family.
    • 细胞定位Golgi apparatus membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CDG2E antibody
      • COG complex subunit 7 antibody
      • cog7 antibody
      • COG7_HUMAN antibody
      • Component of oligomeric Golgi complex 7 antibody
      • Conserved oligomeric Golgi complex component 7 antibody
      • Conserved oligomeric Golgi complex subunit 7 antibody
      see all

    Anti-COG7 antibody 图像

    Anti-COG7 antibody (ab77539)参考文献

    ab77539 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"