概述

  • 产品名称
  • 描述
    山羊多克隆抗体to COG7
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Dog, Cynomolgus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-KTRPEDYRQVSK

    , corresponding to internal sequence amino acids 741-752 of Human COG7 (NP_705831.1)

  • 阳性对照
    • HeLa, Jurkat or MOLT4 golgi lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 85 kDa.
    Peptide ELISA: antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Required for normal Golgi function.
    • 疾病相关
      Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
    • 序列相似性
      Belongs to the COG7 family.
    • 细胞定位
      Golgi apparatus membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CDG2E antibody
      • COG complex subunit 7 antibody
      • cog7 antibody
      • COG7_HUMAN antibody
      • Component of oligomeric Golgi complex 7 antibody
      • Conserved oligomeric Golgi complex component 7 antibody
      • Conserved oligomeric Golgi complex subunit 7 antibody
      see all

    图片

    实验方案

    文献

    ab77539 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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