Anti-Cofilin 2 (phospho S3)抗体(ab14134)


  • 产品名称Anti-Cofilin 2 (phospho S3)抗体
    参阅全部 Cofilin 2 一抗
  • 描述
    兔多克隆抗体to Cofilin 2 (phospho S3)
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Chicken, Human
  • 免疫原

    Synthetic peptide: MASpGVTVNDE-C conjugated to KLH, corresponding to amino acids 1-10 of Human phospho-Cofilin 2 with C-terminal cysteine.

  • 阳性对照
    • RIPA lysates from L6 cells, treated with LIM Kinase for 30 minutes.
  • 常规说明Aliquots are stable for at least 24 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 30% Glycerol, 0.15M Sodium Chloride, 0.1M Tris-glycine. pH 7.4
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab14134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 21 kDa.
ELISA Use at an assay dependent dilution.


  • 功能Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
  • 组织特异性Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
  • 疾病相关Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved.
  • 序列相似性Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.
  • 翻译后修饰The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
  • 细胞定位Nucleus matrix. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CFL 2 antibody
    • CFL2 antibody
    • COF2_HUMAN antibody
    • Cofilin 2 muscle antibody
    • Cofilin antibody
    • Cofilin muscle antibody
    • Cofilin muscle isoform antibody
    • Cofilin-2 antibody
    • Cofilin2 antibody
    • muscle isoform antibody
    • NEM 7 antibody
    • NEM7 antibody
    see all

Anti-Cofilin 2 (phospho S3) antibody (ab14134)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

rr/>Yes, I can confirm that this antibody is raised to recongize the cofilin 2 form which is phosphorylated at the serine in position 3.
I do not know to which extent the antibody does also recognize the unphosphorylated form. Please let me know i...

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To our knowledge, this antibody has yet to be tested in this application. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase this product, please let us know how you get on and in return we will fo...

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