Cofilin 2肽(142-152) (ab45798)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-DIKDRSTLGEK
    • 氨基酸142 to 152

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Cofilin 2 antibody (ab39985)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • CFL 2
    • CFL2
    • COF2_HUMAN
    • Cofilin
    • Cofilin 2 muscle
    • Cofilin muscle
    • Cofilin muscle isoform
    • Cofilin-2
    • Cofilin2
    • muscle isoform
    • NEM 7
    • NEM7
    see all
  • 功能Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
  • 组织特异性Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
  • 疾病相关Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved.
  • 序列相似性Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.
  • 翻译后修饰The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
  • 细胞定位Nucleus matrix. Cytoplasm > cytoskeleton.
  • Information by UniProt

Cofilin 2 peptide (142-152) (ab45798)参考文献

ab45798 has not yet been referenced specifically in any publications.

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