概述

  • 产品名称Anti-Cofilin 2抗体
    参阅全部 Cofilin 2 一抗
  • 描述
    小鼠单克隆抗体to Cofilin 2
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide Recombinant fragment, corresponding to amino acids 57-167 of Human Cofilin 2

性能

应用

Our Abpromise guarantee covers the use of ab54536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 19 kDa.
IHC-P Use a concentration of 8 µg/ml.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
  • 组织特异性Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
  • 疾病相关Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved.
  • 序列相似性Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.
  • 翻译后修饰The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
  • 细胞定位Nucleus matrix. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CFL 2 antibody
    • CFL2 antibody
    • COF2_HUMAN antibody
    • Cofilin 2 muscle antibody
    • Cofilin antibody
    • Cofilin muscle antibody
    • Cofilin muscle isoform antibody
    • Cofilin-2 antibody
    • Cofilin2 antibody
    • muscle isoform antibody
    • NEM 7 antibody
    • NEM7 antibody
    see all

Anti-Cofilin 2 antibody 图像

  • Cofilin 2 antibody (ab54536) used in immunohistochemistry at 8ug/ml on formalin fixed and paraffin embedded human skeletal muscle.


  • Predicted band size : 19 kDa
    Cofilin 2 antibody (ab54536) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • ab54536 at 10 µg/ml staining Cofillin 2 in human Hela cells by Immunocytochemistry / Immunofluorescence.

Anti-Cofilin 2 antibody (ab54536)参考文献

ab54536 has not yet been referenced specifically in any publications.

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