概述

  • 产品名称Anti-CoCoA抗体
    参阅全部 CoCoA 一抗
  • 描述
    兔多克隆抗体to CoCoA
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 1 and 50 of human CoCoA (NP_065949.1)

  • 阳性对照
    • Whole cell lysate from MCF7 cells.

性能

应用

Our Abpromise guarantee covers the use of ab70563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 相关性Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1 mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
    • 细胞定位Cytoplasm. Nucleus. Note: shuttles between nucleus and cytoplasm.
    • 数据库链接
    • 别名
      • Calcium binding and coiled coil domain 1 antibody
      • CALCOCO1 antibody
      • Calphoglin antibody
      • Coiled coil coactivator protein antibody
      • Coiled coil leucine zipper coactivator 1 antibody
      • Coiled coil transcriptional coactivator antibody
      • Inorganic pyrophosphatase activator antibody
      • KIAA1536 antibody
      • PP13275 antibody
      • Sarcoma antigen NY-SAR-3 antibody
      see all

    Anti-CoCoA antibody 图像

    • Detection of human CoCoA by Immunoprecipitation in whole cell lysate from MCF7 cells (1 mg, 20% of immunoprecipitate loaded/lane), using ab70563 at 3 µg/mg of lysate (lane 1).
      CoCoA was also immunoprecipitated using another CoCoA antibody (ab70564) which recognizes a downstream epitope (lane 2).
      Lane 3: Control IgG immunoprecipitate.
      Subsequent blotting of immunoprecipitate for the detection of CoCoA was performed using 1µg/ml of the other antibody (ab70564) and 50µg of lysate. Detection was by chemiluminescence with an exposure time of 30 seconds.

    Anti-CoCoA antibody (ab70563)参考文献

    ab70563 has not yet been referenced specifically in any publications.

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