概述

  • 产品名称Anti-COCH抗体
    参阅全部 COCH 一抗
  • 描述
    小鼠多克隆抗体to COCH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-494 of Human COCH

  • 阳性对照
    • COCH transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab72581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 54 kDa.

靶标

  • 功能Plays a role in the control of cell shape and motility in the trabecular meshwork.
  • 组织特异性Expressed in inner ear structures; the cochlea and the vestibule.
  • 疾病相关Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9) [MIM:601369]. DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.
  • 序列相似性Contains 1 LCCL domain.
    Contains 2 VWFA domains.
  • 翻译后修饰N-glycosylated.
    A 50 kDa form is created by proteolytic cleavage.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Coagulation factor C homolog, cochlin (Limulus polyphemus) antibody
    • COCH antibody
    • COCH-5B2 antibody
    • COCH_HUMAN antibody
    • COCH5B2 antibody
    • Cochlin antibody
    • DFNA9 antibody
    see all

Anti-COCH antibody 图像

  • All lanes : Anti-COCH antibody (ab72581) at 1/500 dilution

    Lane 1 : COCH transfected 293T cell lysate
    Lane 2 : non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

Anti-COCH antibody (ab72581)参考文献

ab72581 has not yet been referenced specifically in any publications.

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