概述

  • 产品名称
  • 描述
    兔多克隆抗体to CNG3
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human CNG3.

    (Peptide available as ab109061.)

  • 阳性对照
    • This antibody gave a positive signal in Mouse Retina Tissue Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab97500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 79 kDa (predicted molecular weight: 79 kDa).

靶标

  • 功能
    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
  • 组织特异性
    Prominently expressed in retina.
  • 疾病相关
    Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night.
  • 序列相似性
    Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.
    Contains 1 cyclic nucleotide-binding domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ACHM2 antibody
    • CCNC1 antibody
    • CCNCa antibody
    • CCNCalpha antibody
    • CNCG3 antibody
    • CNG 3 antibody
    • CNG channel alpha 3 antibody
    • CNG channel alpha-3 antibody
    • CNG-3 antibody
    • CNG3 antibody
    • CNGA3 antibody
    • Cnga3 cyclic nucleotide gated channel alpha 3 antibody
    • CNGA3_HUMAN antibody
    • Cone photoreceptor cGMP gated channel antibody
    • Cone photoreceptor cGMP gated channel alpha subunit antibody
    • Cone photoreceptor cGMP gated channel subunit alpha antibody
    • Cone photoreceptor cGMP-gated channel subunit alpha antibody
    • Cyclic nucleotide gated cation channel alpha 3 antibody
    • Cyclic nucleotide gated channel alpha 3 antibody
    • Cyclic nucleotide gated channel olfactory 3 antibody
    • Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody
    • Cyclic nucleotide-gated cation channel alpha-3 antibody
    • Cyclic nucleotide-gated channel alpha-3 antibody
    • OTTHUMP00000161120 antibody
    see all

图片

  • Anti-CNG3 antibody (ab97500) at 1 µg/ml + Mouse Retina Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 79 kDa
    Observed band size : 79 kDa
    Additional bands at : 46 kDa,55 kDa,70 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

实验方案

文献

ab97500 has not yet been referenced specifically in any publications.

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