Anti-CNG1抗体[S36-12] (ab105878)

概述

  • 产品名称Anti-CNG1抗体[S36-12]
    参阅全部 CNG1 一抗
  • 描述
    小鼠单克隆抗体[S36-12] to CNG1
  • 特异性Recognizes both rod and cone alpha subunits.
  • 经测试应用适用于: WB, IHC-P, IHC-Fr, ICC, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Fish
  • 免疫原

    Fusion protein corresponding to the cytoplasmic C terminal amino acids 535-637 of Goldfish CNG1 (AAO16601).

性能

应用

Our Abpromise guarantee covers the use of ab105878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 80 kDa.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
ICC Use a concentration of 0.1 - 1 µg/ml.
ICC/IF Use a concentration of 1 - 10 µg/ml.

靶标

  • 功能Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
  • 组织特异性Rod cells in the retina.
  • 疾病相关Defects in CNGA1 are the cause of retinitis pigmentosa type 49 (RP49) [MIM:613756]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
    Contains 1 cyclic nucleotide-binding domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cGMP gated cation channel alpha 1 antibody
    • cGMP-gated cation channel alpha-1 antibody
    • CNCG antibody
    • CNCG1 antibody
    • CNG 1 antibody
    • CNG channel alpha 1 antibody
    • CNG channel alpha-1 antibody
    • CNG-1 antibody
    • CNG1 antibody
    • Cnga1 antibody
    • CNGA1_HUMAN antibody
    • Cyclic nucleotide gated cation channel 1 antibody
    • Cyclic nucleotide gated channel alpha 1 antibody
    • Cyclic nucleotide gated channel photoreceptor antibody
    • Cyclic nucleotide-gated cation channel 1 antibody
    • Cyclic nucleotide-gated channel alpha-1 antibody
    • Cyclic nucleotide-gated channel antibody
    • Interleukin 1 homologue antibody
    • OTTHUMP00000218675 antibody
    • OTTHUMP00000223313 antibody
    • OTTHUMP00000223314 antibody
    • photoreceptor antibody
    • RCNC1 antibody
    • RCNCa antibody
    • RCNCalpha antibody
    • Rod photoreceptor cGMP gated channel subunit alpha antibody
    • Rod photoreceptor cGMP-gated channel subunit alpha antibody
    • RP49 antibody
    see all

Anti-CNG1 antibody [S36-12] 图像

  • Immunohistochemical detection of CNG1 using ab105878 in Mouse eye retina. Staining of the nervous fibers top right. Weak staining of the econd level of the retina neurons (center).


  • Predicted band size : 80 kDa
    Western blot detection of CNG1 in Human retina lysate using ab105878 at 1:1000 dilution.

Anti-CNG1 antibody [S36-12] (ab105878)参考文献

ab105878 has not yet been referenced specifically in any publications.

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