概述

  • 产品名称
  • 描述
    兔多克隆抗体to CMPK2
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 150-180 of Human CMPK2.

  • 阳性对照
    • Hela cell line lysates; Human prostate carcinoma tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab103658 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab103658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 49 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.
  • 组织特异性
    Among all investigated tumors, leukemia cells show the most abundant expression.
  • 序列相似性
    Belongs to the thymidylate kinase family.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1200004E04Rik antibody
    • Cmpk2 antibody
    • CMPK2_HUMAN antibody
    • Cytidine monophosphate (UMP CMP) kinase 2, mitochondrial antibody
    • mitochondrial antibody
    • Mitochondrial UMP CMP kinase antibody
    • OTTHUMP00000200305 antibody
    • Thymidine monophosphate kinase 2 antibody
    • TMPK2 antibody
    • TYKi antibody
    • UMP CMP kinase 2, mitochondrial antibody
    • UMP CMP kinase 2, mitochondrial; cytidylate kinase 2 antibody
    • UMP CMPK2 antibody
    • UMP-CMP kinase 2 antibody
    see all

图片

  • Anti-CMPK2 antibody (ab103658) at 1/100 dilution + Hela cell line lysates at 35 µg

    Predicted band size : 49 kDa
  • ab103658 at 1/50 dilution, staining CMPK2 in Human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.

文献

This product has been referenced in:
  • Topalis D  et al. Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1. Oncotarget 7:10386-401 (2016). WB . Read more (PubMed: 26824416) »

See 1 Publication for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab103658.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册