概述

  • 产品名称Anti-CLNK抗体
    参阅全部 CLNK 一抗
  • 描述
    兔多克隆抗体to CLNK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 280-308 of Human CLNK (NP_443196.2).

  • 阳性对照
    • HepG2 cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab116287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT.
  • 序列相似性Contains 1 SH2 domain.
  • 结构域The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
    The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
  • 翻译后修饰Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLNK antibody
    • CLNK_HUMAN antibody
    • Cytokine-dependent hematopoietic cell linker antibody
    • Mast cell immunoreceptor signal transducer antibody
    • MGC159342, antibody
    • MGC35197 antibody
    • MIST antibody
    • RGD1562417 antibody
    see all

Anti-CLNK antibody 图像

  • Anti-CLNK antibody (ab116287) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 50 kDa

Anti-CLNK antibody (ab116287)参考文献

ab116287 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116287.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"