概述

  • 产品名称Anti-CLIC2抗体
    参阅全部 CLIC2 一抗
  • 描述
    小鼠多克隆抗体to CLIC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human CLIC2 protein (NP_001280.3)

  • 阳性对照
    • Human spleen tissue lysate and CLIC2 transfected 293T cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).

靶标

  • 功能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
  • 组织特异性Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle.
  • 序列相似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • 结构域Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 细胞定位Cytoplasm. Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chloride intracellular channel 2 antibody
    • Chloride intracellular channel protein 2 antibody
    • CLIC 2b antibody
    • CLIC2 antibody
    • CLIC2_HUMAN antibody
    • CLIC2b antibody
    • MRXS32 antibody
    • OTTHUMP00000196471 antibody
    • XAP 121 antibody
    • XAP121 antibody
    see all

Anti-CLIC2 antibody 图像

  • Anti-CLIC2 antibody (ab89916) at 1 µg/ml + Human spleen tissue lysate at 50 µg

    Predicted band size : 28 kDa
    Observed band size : 28 kDa
    Additional bands at : 26 kDa,35 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-CLIC2 antibody (ab89916) at 1 µg/ml

    Lane 1 : CLIC2 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 28 kDa
    Observed band size : 28 kDa

Anti-CLIC2 antibody (ab89916)参考文献

ab89916 has not yet been referenced specifically in any publications.

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