概述

  • 产品名称Anti-CLIC1抗体
    参阅全部 CLIC1 一抗
  • 描述
    兔多克隆抗体to CLIC1
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human CLIC1 protein

  • 阳性对照
    • A375 cell line lysates; human prostate carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab76592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 27 kDa.
ELISA 1/1000.
IHC-P 1/10 - 1/50.

靶标

  • 功能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
  • 组织特异性Expression is prominent in heart, placenta, liver, kidney and pancreas.
  • 序列相似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • 结构域Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 翻译后修饰Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
  • 细胞定位Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chloride channel ABP antibody
    • Chloride intracellular channel 1 antibody
    • Chloride intracellular channel protein 1 antibody
    • CLIC 1 antibody
    • CLIC1 antibody
    • CLIC1_HUMAN antibody
    • G6 antibody
    • hRNCC antibody
    • NCC 27 antibody
    • NCC27 antibody
    • Nuclear chloride ion channel 27 antibody
    • Nuclear chloride ion channel protein antibody
    • p64CLCP antibody
    • Regulatory nuclear chloride ion channel protein antibody
    • RNCC protein antibody
    see all

Anti-CLIC1 antibody 图像

  • Anti-CLIC1 antibody (ab76592) at 1/60 dilution + A375 cell line lysates at 35 µg

    Predicted band size : 27 kDa
    Observed band size : 27 kDa
  • ab76592, at a 1/10 dilution, staining CLIC1 in formalin fixed, paraffin embedded human prostate carcinoma tissue by Immunohistochemistry. ab76592 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-CLIC1 antibody (ab76592)参考文献

ab76592 has not yet been referenced specifically in any publications.

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