概述

  • 产品名称Anti-CLIC1抗体
    参阅全部 CLIC1 一抗
  • 描述
    小鼠单克隆抗体to CLIC1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-242 of Human CLIC1

性能

应用

Our Abpromise guarantee covers the use of ab54680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
    • 组织特异性Expression is prominent in heart, placenta, liver, kidney and pancreas.
    • 序列相似性Belongs to the chloride channel CLIC family.
      Contains 1 GST C-terminal domain.
    • 结构域Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
    • 翻译后修饰Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
    • 细胞定位Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Chloride channel ABP antibody
      • Chloride intracellular channel 1 antibody
      • Chloride intracellular channel protein 1 antibody
      • CLIC 1 antibody
      • CLIC1 antibody
      • CLIC1_HUMAN antibody
      • G6 antibody
      • hRNCC antibody
      • NCC 27 antibody
      • NCC27 antibody
      • Nuclear chloride ion channel 27 antibody
      • Nuclear chloride ion channel protein antibody
      • p64CLCP antibody
      • Regulatory nuclear chloride ion channel protein antibody
      • RNCC protein antibody
      see all

    Anti-CLIC1 antibody 图像



    • Predicted band size : 27 kDa
      CLIC1 antibody (ab54680) at 1ug/lane + 293 cell lysate at 25ug/lane.

    Anti-CLIC1 antibody (ab54680)参考文献

    ab54680 has not yet been referenced specifically in any publications.

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