Anti-CLEC5A抗体(ab89060)

概述

  • 产品名称Anti-CLEC5A抗体
    参阅全部 CLEC5A 一抗
  • 描述
    小鼠多克隆抗体to CLEC5A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human CLEC5A protein (NP_037384.1).

  • 阳性对照
    • Human liver tissue lysate and CLEC5A transfected 293T cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa.

靶标

  • 功能Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • 组织特异性Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
  • 序列相似性Contains 1 C-type lectin domain.
  • 翻译后修饰N-glycosylated. Contains sialic acid residues.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C type lectin domain family 5 member A antibody
    • C-type lectin domain family 5 member A antibody
    • C-type lectin superfamily member 5 antibody
    • CLC5A_HUMAN antibody
    • CLEC5 A antibody
    • CLEC5A antibody
    • CLECSF 5 antibody
    • CLECSF5 antibody
    • MDL 1 antibody
    • MDL-1 antibody
    • MDL1 antibody
    • Myeloid DAP12 associating lectin antibody
    • Myeloid DAP12-associating lectin 1 antibody
    see all

Anti-CLEC5A antibody 图像

  • Anti-CLEC5A antibody (ab89060) at 1 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 22 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-CLEC5A antibody (ab89060) at 1 µg/ml

    Lane 1 : CLEC5A transfected 293T cell line lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 22 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 36 kDa. We are unsure as to the identity of these extra bands.

Anti-CLEC5A antibody (ab89060)参考文献

ab89060 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"