Anti-CLEC5A抗体(ab66425)

概述

  • 产品名称Anti-CLEC5A抗体
    参阅全部 CLEC5A 一抗
  • 描述
    兔多克隆抗体to CLEC5A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human CLEC5A.

    (Peptide available as ab87123.)

  • 阳性对照
    • This antibody gave a positive signal in U937 Whole Cell Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab66425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 22 kDa).

靶标

  • 功能Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • 组织特异性Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
  • 序列相似性Contains 1 C-type lectin domain.
  • 翻译后修饰N-glycosylated. Contains sialic acid residues.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C type lectin domain family 5 member A antibody
    • C-type lectin domain family 5 member A antibody
    • C-type lectin superfamily member 5 antibody
    • CLC5A_HUMAN antibody
    • CLEC5 A antibody
    • CLEC5A antibody
    • CLECSF 5 antibody
    • CLECSF5 antibody
    • MDL 1 antibody
    • MDL-1 antibody
    • MDL1 antibody
    • Myeloid DAP12 associating lectin antibody
    • Myeloid DAP12-associating lectin 1 antibody
    see all

Anti-CLEC5A antibody 图像

  • Anti-CLEC5A antibody (ab66425) at 1 µg/ml + U937 (Human leukemic monocyte lymphoma cell line) Whole Cell Lysate at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 22 kDa
    Observed band size : 28 kDa (why is the actual band size different from the predicted?)

Anti-CLEC5A antibody (ab66425)参考文献

ab66425 has not yet been referenced specifically in any publications.

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